Podoconiosis: a tropical model for gene–environment interactions?
Identifieur interne : 007378 ( Main/Exploration ); précédent : 007377; suivant : 007379Podoconiosis: a tropical model for gene–environment interactions?
Auteurs : Gail Davey [Éthiopie] ; Ewenat Gebrehanna [Éthiopie] ; Adebowale Adeyemo [États-Unis] ; Charles Rotimi [États-Unis] ; Melanie Newport [Royaume-Uni] ; Kelemu Desta [Éthiopie]Source :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2007-01.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Éléphantiasis.
- épidémiologie : Éléphantiasis, Éthiopie.
- Facteurs de risque, Femelle, Humains, Mâle, Pedigree, Récidive, Santé en zone rurale, Âge de début.
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Age of Onset, Elephantiasis, Elephantiasis (epidemiology), Elephantiasis (genetics), Ethiopia, Ethiopia (epidemiology), Female, Genetic susceptibility, Genetics, Gene–environment interaction, Genotype environment interaction, Geochemical, Heritability, Human, Humans, Lymphedema, Male, Models, Pedigree, Podoconiosis, Predisposition, Recurrence, Risk Factors, Rural Health, Sensitivity, Tropical medicine.
- MESH :
- geographic , epidemiology : Ethiopia.
- epidemiology : Elephantiasis.
- genetics : Elephantiasis.
- Age of Onset, Female, Humans, Male, Pedigree, Recurrence, Risk Factors, Rural Health.
Abstract
Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (λs) and heritability for podoconiosis, and conducted segregation analysis on 59 multigenerational affected families from Wolaitta Zone, southern Ethiopia. We estimated the λs to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P = 1 × 10−7). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene–environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.
Url:
DOI: 10.1016/j.trstmh.2006.05.002
Affiliations:
- Royaume-Uni, États-Unis, Éthiopie
- Angleterre, District de Columbia, Sussex de l'Est
- Brighton, Falmer, Washington (district de Columbia)
- Université du Sussex
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Le document en format XML
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Box 251, Sodo, Wolaitta</wicri:regionArea><wicri:noRegion>Wolaitta</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of The Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title><idno type="ISSN">0035-9203</idno><idno type="eISSN">1878-3503</idno><imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><date type="published" when="2007-01">2007-01</date><biblScope unit="volume">101</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="91">91</biblScope><biblScope unit="page" to="96">96</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Elephantiasis</term><term>Elephantiasis (epidemiology)</term><term>Elephantiasis (genetics)</term><term>Ethiopia</term><term>Ethiopia (epidemiology)</term><term>Female</term><term>Genetic susceptibility</term><term>Genetics</term><term>Gene–environment interaction</term><term>Genotype environment interaction</term><term>Geochemical</term><term>Heritability</term><term>Human</term><term>Humans</term><term>Lymphedema</term><term>Male</term><term>Models</term><term>Pedigree</term><term>Podoconiosis</term><term>Predisposition</term><term>Recurrence</term><term>Risk Factors</term><term>Rural Health</term><term>Sensitivity</term><term>Tropical medicine</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pedigree</term><term>Récidive</term><term>Santé en zone rurale</term><term>Âge de début</term><term>Éléphantiasis (génétique)</term><term>Éléphantiasis (épidémiologie)</term><term>Éthiopie (épidémiologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ethiopia</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Elephantiasis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Éléphantiasis</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Éléphantiasis</term><term>Éthiopie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Female</term><term>Humans</term><term>Male</term><term>Pedigree</term><term>Recurrence</term><term>Risk Factors</term><term>Rural Health</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pedigree</term><term>Récidive</term><term>Santé en zone rurale</term><term>Âge de début</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Eléphantiasis</term><term>Ethiopie</term><term>Génétique</term><term>Homme</term><term>Héritabilité</term><term>Interaction génotype environnement</term><term>Lymphoedème</term><term>Modèle</term><term>Médecine tropicale</term><term>Podoconiose</term><term>Prédisposition</term><term>Sensibilité</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Éthiopie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (λs) and heritability for podoconiosis, and conducted segregation analysis on 59 multigenerational affected families from Wolaitta Zone, southern Ethiopia. We estimated the λs to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P = 1 × 10−7). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene–environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li><li>Éthiopie</li></country><region><li>Angleterre</li><li>District de Columbia</li><li>Sussex de l'Est</li></region><settlement><li>Brighton</li><li>Falmer</li><li>Washington (district de Columbia)</li></settlement><orgName><li>Université du Sussex</li></orgName></list><tree><country name="Éthiopie"><noRegion><name sortKey="Davey, Gail" sort="Davey, Gail" uniqKey="Davey G" first="Gail" last="Davey">Gail Davey</name></noRegion><name sortKey="Davey, Gail" sort="Davey, Gail" uniqKey="Davey G" first="Gail" last="Davey">Gail Davey</name><name sortKey="Desta, Kelemu" sort="Desta, Kelemu" uniqKey="Desta K" first="Kelemu" last="Desta">Kelemu Desta</name><name sortKey="Gebrehanna, Ewenat" sort="Gebrehanna, Ewenat" uniqKey="Gebrehanna E" first="Ewenat" last="Gebrehanna">Ewenat Gebrehanna</name></country><country name="États-Unis"><region name="District de Columbia"><name sortKey="Adeyemo, Adebowale" sort="Adeyemo, Adebowale" uniqKey="Adeyemo A" first="Adebowale" last="Adeyemo">Adebowale Adeyemo</name></region><name sortKey="Rotimi, Charles" sort="Rotimi, Charles" uniqKey="Rotimi C" first="Charles" last="Rotimi">Charles Rotimi</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Newport, Melanie" sort="Newport, Melanie" uniqKey="Newport M" first="Melanie" last="Newport">Melanie Newport</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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